|
|
2-(Hydroxymethyl)-3-(acetamidomethylene)succinate + H2O + H+ <=> 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH3
|
3.5.1.66
2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
|
–
|
|
BRENDA:
BR19253
KEGG:
R04397
MetaCyc:
3.5.1.66-RXN
|
|
|
|
pyridoxine_5''-phosphate + H2O <=> pyridoxine + phosphate
|
3.1.3.2
acid phosphatase
3.1.3.74
pyridoxal phosphatase
|
–
–
|
|
BRENDA:
BS374485
KEGG:
R01911
MetaCyc:
RXN-14181
SABIO-RK:
1965
|
|
|
|
1-deoxy-D-xylulose_5-phosphate + 3-amino-1-hydroxyacetone_1-phosphate <=> H+ + pyridoxine_5''-phosphate + phosphate + H2O
|
2.6.99.2
pyridoxine 5'-phosphate synthase
|
–
|
|
BRENDA:
BR48673
KEGG:
R05838
MetaCyc:
PDXJ-RXN
|
|
|
|
pyridoxamine + O2 + H2O <=> pyridoxal + NH3 + H2O2
|
1.4.3
1.4.3.5
pyridoxal 5'-phosphate synthase
|
–
–
|
|
KEGG:
R01710
MetaCyc:
RXN-14203
|
|
|
|
pyridoxal + ATP <=> pyridoxal_5''-phosphate + H+ + ADP
|
2.7.1.35
pyridoxal kinase
|
–
|
|
BRENDA:
BR47774
KEGG:
R00174
MetaCyc:
PYRIDOXKIN-RXN
SABIO-RK:
729
|
|
|
|
4-phospho-D-erythronate + NAD+ <=> H+ + 3-hydroxy-2-oxo-4-(phosphonooxy)butanoate + NADH
|
1.1.1.290
4-phosphoerythronate dehydrogenase
|
–
|
|
BRENDA:
BR48652;
BS378673
KEGG:
R04210
MetaCyc:
ERYTHRON4PDEHYDROG-RXN
|
|
|
|
D-erythrose_4-phosphate + NAD+ + H2O <=> 4-phospho-D-erythronate + NADH + H+
|
1.2.1.72
erythrose-4-phosphate dehydrogenase
|
–
|
|
BRENDA:
BR48654
KEGG:
R01825
MetaCyc:
ERYTH4PDEHYDROG-RXN
SABIO-RK:
1909
|
|
|
|
pyridoxamine + 2-oxoglutarate <=> pyridoxal + D-glutamate
|
2.6.1.31
pyridoxamine---oxaloacetate transaminase
2.6.1.54
pyridoxamine-phosphate transaminase
|
–
–
|
|
BRENDA:
BS354480
KEGG:
R05839
SABIO-RK:
5430
|
|
|
|
pyridoxine + O2 <=> Isopyridoxal + H2O2
|
1.1.99.9
pyridoxine 5-dehydrogenase
|
–
|
|
BRENDA:
BS451176
KEGG:
R01910
|
|
|
|
3-Hydroxy-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 <=> 2-(Acetamidomethylene)succinate + NADP+
|
1.14.13.242
3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase
|
–
|
|
BRENDA:
BR40442
KEGG:
R03386
|
|
|
|
H+ + 3-hydroxy-2-methylpyridine-4,5-dicarboxylate <=> CO2 + 3-Hydroxy-2-methylpyridine-5-carboxylate
|
4.1.1.51
3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase
|
–
|
|
BRENDA:
BR311
KEGG:
R03461
MetaCyc:
4.1.1.51-RXN
|
|
|
|
4-phosphooxy-L-threonine + H2O <=> L-4-hydroxythreonine + phosphate
|
4.2.3
4.2.3.1
threonine synthase
|
–
–
|
|
KEGG:
R05086
MetaCyc:
RXN-14125
|
|
|
|
pyridoxal + NAD+ <=> 4-Pyridoxolactone + NADH + H+
|
1.1.1.107
pyridoxal 4-dehydrogenase
|
–
|
|
BRENDA:
BR29173
KEGG:
R01707
MetaCyc:
PYRIDOXAL-4-DEHYDROGENASE-RXN
SABIO-RK:
1819
|
|
|
|
ATP + pyridoxamine <=> H+ + ADP + pyridoxamine_5''-phosphate
|
2.7.1.35
pyridoxal kinase
2.7.1.49
hydroxymethylpyrimidine kinase
|
–
–
|
|
BRENDA:
BS357527
KEGG:
R02493
MetaCyc:
PYRAMKIN-RXN
|
|
|
|
O2 + H2O + pyridoxamine_5''-phosphate <=> NH3 + H2O2 + pyridoxal_5''-phosphate
|
1.4.3.5
pyridoxal 5'-phosphate synthase
|
–
|
|
BRENDA:
BR36881
KEGG:
R00277
MetaCyc:
PMPOXI-RXN
SABIO-RK:
777
|
|
|
|
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD+ <=> 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+
|
1.2.1.100
5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase
|
–
|
|
BRENDA:
BR52387
KEGG:
R04524
MetaCyc:
RXN-8756
SABIO-RK:
4202
|
|
|
|
D-ribose_5-phosphate + D-glyceraldehyde_3-phosphate + L-glutamine <=> pyridoxal_5''-phosphate + L-glutamate + 3 H2O + phosphate
|
4.3.3.6
pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
|
–
|
|
BRENDA:
BR50350;
BS426244
KEGG:
R10089
|
|
|
|
4-pyridoxate + acceptor <=> 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + reduced_acceptor
|
1.1.99.42
4-pyridoxic acid dehydrogenase
|
–
|
|
BRENDA:
BR52386
KEGG:
R02993
MetaCyc:
RXN-8757
|
|
|
|
Isopyridoxal + NAD+ + H2O <=> nicotinate + NADH + H+
|
1.2.1.102
isopyridoxal dehydrogenase (5-pyridoxate-forming)
|
–
|
|
BRENDA:
BR52560
KEGG:
R12265
MetaCyc:
RXN-19620
|
|
|
|
pyridoxamine_5''-phosphate + 2-oxoglutarate <=> pyridoxal_5''-phosphate + D-glutamate
|
2.6.1.54
pyridoxamine-phosphate transaminase
|
–
|
|
BRENDA:
BR47477
KEGG:
R01580
MetaCyc:
PYRDAMPTRANS-RXN
|
|
|
|
H2O + 4-Pyridoxolactone <=> H+ + 4-pyridoxate
|
3.1.1.27
4-pyridoxolactonase
|
–
|
|
BRENDA:
BR10650
KEGG:
R02992
MetaCyc:
4-PYRIDOXOLACTONASE-RXN
|
|
|
|
pyridoxine <=> 1-deoxy-D-xylulose + L-4-hydroxythreonine
|
not assigned
|
–
|
|
KEGG:
R01913
|
|
|
|
ATP + pyridoxine <=> H+ + ADP + pyridoxine_5''-phosphate
|
2.7.1.35
pyridoxal kinase
2.7.1.49
hydroxymethylpyrimidine kinase
|
–
–
|
|
BRENDA:
BS357525
KEGG:
R01909
MetaCyc:
PNKIN-RXN
SABIO-RK:
1963
|
|
|
|
(2S)-2-amino-3-oxo-4-phosphonooxybutanoate + H+ <=> 3-amino-1-hydroxyacetone_1-phosphate + CO2
|
0.0.0.0
1.1.1.262
4-hydroxythreonine-4-phosphate dehydrogenase
|
–
–
|
|
BRENDA:
BR52880;
BS371620
KEGG:
R07406
|
|
|
|
pyridoxamine_5''-phosphate + H2O <=> pyridoxamine + phosphate
|
3.1.3.2
acid phosphatase
3.1.3.74
pyridoxal phosphatase
|
–
–
|
|
BRENDA:
BS374481
KEGG:
R02494
MetaCyc:
RXN-14046
SABIO-RK:
2424
|
|
|
|
4-phosphooxy-L-threonine + 2-oxoglutarate <=> 3-hydroxy-2-oxo-4-(phosphonooxy)butanoate + L-glutamate
|
2.6.1.52
phosphoserine transaminase
|
–
|
|
BRENDA:
BR52120;
BS422428
KEGG:
R05085
MetaCyc:
PSERTRANSAMPYR-RXN
|
|
|
|
nicotinate + O2 + NADPH <=> 2-(Hydroxymethyl)-3-(acetamidomethylene)succinate + NADP+
|
1.14.13.241
5-pyridoxate monooxygenase
|
–
|
|
BRENDA:
BR40441
KEGG:
R04570
MetaCyc:
5-PYRIDOXATE-DIOXYGENASE-RXN
|
|
|
|
glycolaldehyde + 2-oxobutyrate + L-alanine <=> pyridoxine
|
not assigned
|
–
|
|
KEGG:
R05840
|
|
|
|
3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate <=> 5-Pyridoxolactone + H2O
|
not assigned
|
–
|
|
KEGG:
R04593
|
|
|
|
O2 + H2O + pyridoxal <=> H+ + H2O2 + 4-pyridoxate
|
1.2.3.1
aldehyde oxidase
1.2.3.8
pyridoxal oxidase
|
–
–
|
|
BRENDA:
BS258253
KEGG:
R01709
MetaCyc:
PYRIDOXAL-OXIDASE-RXN
|
|
|
|
pyruvate + pyridoxamine <=> L-alanine + pyridoxal
|
2.6.1.30
pyridoxamine---pyruvate transaminase
|
–
|
|
BRENDA:
BR47682
KEGG:
R01712
MetaCyc:
2.6.1.30-RXN
SABIO-RK:
1824
|
|
|
|
pyridoxamine + oxaloacetate <=> pyridoxal + L-aspartate
|
2.6.1.31
pyridoxamine---oxaloacetate transaminase
|
–
|
|
BRENDA:
BR47683
KEGG:
R01713
MetaCyc:
PYROXALTRANSAM-RXN
SABIO-RK:
1825
|
|
|
|
3-Hydroxy-2-methylpyridine-5-carboxylate + NADH + H+ + O2 <=> 2-(Acetamidomethylene)succinate + NAD+
|
1.14.13.242
3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase
|
–
|
|
BRENDA:
BR40442-a
KEGG:
R03385
SABIO-RK:
3189
|
|
|
|
pyridoxine + O2 <=> pyridoxal + H2O2
|
1.1.3.12
pyridoxine 4-oxidase
1.4.3.5
pyridoxal 5'-phosphate synthase
|
–
–
|
|
BRENDA:
BR36730
KEGG:
R01711
MetaCyc:
PYRIDOXINE-4-OXIDASE-RXN
|
|
|
|
Isopyridoxal + NAD+ <=> 5-Pyridoxolactone + NADH + H+
|
1.1.1.416
isopyridoxal dehydrogenase (5-pyridoxolactone-forming)
|
–
|
|
BRENDA:
BR52559
KEGG:
R05084
MetaCyc:
RXN-19621
SABIO-RK:
11504
|
|
|
|
4-(phosphonooxy)-L-threonine + NAD+ <=> 2-amino-3-oxo-4-phosphonooxybutyrate + NADH
|
1.1.1.262
4-hydroxythreonine-4-phosphate dehydrogenase
|
–
|
|
BRENDA:
BS139544
KEGG:
R05681
|
|
|
|
O2 + pyridoxine_5''-phosphate <=> H2O2 + pyridoxal_5''-phosphate
|
1.4.3.5
pyridoxal 5'-phosphate synthase
|
–
|
|
BRENDA:
BR48819
KEGG:
R00278
MetaCyc:
PNPOXI-RXN
SABIO-RK:
778
|
|
|
|
pyridoxal_5''-phosphate + H2O <=> pyridoxal + phosphate
|
3.1.3.2
acid phosphatase
3.1.3.26
4-phytase
3.1.3.74
pyridoxal phosphatase
3.1.3.8
3-phytase
|
–
–
–
–
|
|
BRENDA:
BR48524
KEGG:
R00173
MetaCyc:
3.1.3.74-RXN
SABIO-RK:
728
|
|
|
|
NADP+ + pyridoxine <=> H+ + NADPH + pyridoxal
|
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.65
pyridoxine 4-dehydrogenase
|
–
–
|
|
BRENDA:
BR29329
KEGG:
R01708
MetaCyc:
PYRIDOXINE-4-DEHYDROGENASE-RXN
SABIO-RK:
1820
|
|
|
|
2-(Acetamidomethylene)succinate + 2 H2O <=> acetate + succinate_semialdehyde + NH3 + CO2
|
3.5.1.29
2-(acetamidomethylene)succinate hydrolase
3.5.1.66
2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
|
–
–
|
|
BRENDA:
BR19243
KEGG:
R01649
|
|